DESCOVY® for HIV-1 pre-exposure prophylaxis (PrEP) is indicated in at-risk adults and adolescents (≥35 kg) to reduce the risk of sexually acquired HIV-1 infection, excluding individuals at risk from receptive vaginal sex. HIV-1–negative status must be confirmed immediately prior to initiation.

Limitation of Use: DESCOVY FOR PrEP® is not indicated in individuals at risk of HIV-1 from receptive vaginal sex because effectiveness in this population has not been evaluated.

HIV prevention with the long term in mind

HIV risk does not discriminate—it affects sexually active individuals of all ages and can last throughout their lives1

Because HIV risk may persist, patients may look at using a PrEP medication for longer periods of time. In fact, one study (n=1402) found that almost 50% of PrEP patients had an active prescription for >3 years.2

Renal exposure may matter more over time3,4

Kidney icon in blue

People may already be experiencing declines in eGFR due to age

Markers of renal function that can be affected by exposure to certain drugs include

• eGFR

• Serum creatinine

Mean GFR values across life span in males

Graph Showing Mean GFR Values in Normal Males

Reprinted with permission from Elsevier.4

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Since renal exposure may matter more over time, consider factors that impact parameters of renal function when choosing a PrEP option for your patients.

Bone density is crucial for your patients of any age5-7

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Bone density develops through age 30 and decreases as people age

• Under 30: They are often still building bone

• Over 40: They may already be experiencing bone mineral density declines

Bone mass across life span in males

Graph showing bone mass across lifespan in males

Adapted by permission from Springer Nature: Osteoporosis International. The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations, Weaver CM, Gordon CM, Janz KF, et al, 2016.6

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Since bone density is crucial at any age, choose a PrEP option for patients with bone mineral density in mind.

eGFR=estimated glomerular filtration rate.