Less impact on markers of renal function across populations1

DESCOVY® had less long-term impact on markers of renal function vs FTC/TDF1,2

Median change in eGFRCG through Week 96

There was a 4.1 mL/min difference between DESCOVY FOR PrEP® (+3.7 mL/min) and FTC/TDF (-0.4 mL/min) in eGFRCG at Week 96.2

The long-term clinical significance of changes in eGFR is not known.

DISCOVER TRIAL BASELINE CHARACTERISTICS

Lower serum creatinine levels were also seen with DESCOVY FOR PrEP through Week 96

  • Median serum creatinine decreased 0.02 mg/dL with DESCOVY FOR PrEP vs a 0.01 mg/dL decrease with FTC/TDF from baseline at Week 96
  • DESCOVY FOR PrEP can be used in people with impaired renal function of CrCl ≥30 mL/min

eGFR remained steady over 144 weeks with DESCOVY®2,3

Analysis of eGFR from baseline to ≥144 weeks (DESCOVY)

Median change in eGFR

Graph displaying DESCOVY® (emtricitabine/tenofovir alafenamide) median change in eGFR through week 144. See BOXED WARNING.

The long-term clinical significance of changes in eGFR is not known.

DISCOVER TRIAL BASELINE CHARACTERISTICS

DESCOVY® had less long-term impact on eGFR in participants ≥50 years of age2,4

Results were seen in participants of an age group that may already be experiencing age-associated declines

Median change in eGFRCG in participants ≥50 years of age through Week 96

There was a 4.4 mL/min difference between DESCOVY FOR PrEP® (+1.2 mL/min) and FTC/TDF (-3.2 mL/min) in eGFRCG at Week 96.4

The long-term clinical significance of changes in eGFR is not known.

DISCOVER TRIAL BASELINE CHARACTERISTICS

Resource

Renal Risk Factor Brochure

A resource with information about why renal function is an important consideration when prescribing PrEP medication. Includes risk factors that may impact renal function.

Download

DESCOVY FOR PrEP® can be used in people with impaired renal function of CrCl ≥30 mL/min.2

CrCl=creatinine clearance; eGFRCG=estimated glomerular filtration rate (Cockcroft-Gault); FTC/TDF=emtricitabine/tenofovir disoproxil fumarate; Q1, Q3=first quartile, third quartile.

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