TAF Pharmacology

PrEP drug molecules are different1-6

DESCOVY® contains TAF, which more efficiently delivers tenofovir DP into PBMCs (including lymphocytes like CD4+ T cells) and macrophages vs TDF1-4

Get the details on the only TAF-based PrEP medication.1

Up to 90% less tenofovir in plasma with TAF vs TDF

Graphic showing plasma half-life of tenofovir from TAF vs TDF and levels in lymphocytes

Up to 7x higher mean levels of tenofovir DP in lymphocytes with TAF vs TDF

Up to 90% less tenofovir in plasma with TAF vs TDF

Graphic showing plasma half-life of tenofovir from TAF vs TDF and levels in lymphocytes

Up to 7x higher mean levels of tenofovir DP in lymphocytes with TAF vs TDF

TAF delivers more active drug to lymphocytes vs TDF, resulting in less off-target drug exposure.

VIEW THE DISCOVER TRIAL

a Plasma half-life: TAF=30 minutes; TDF=0.41 minutes.4,6
b Tenofovir is converted into tenofovir DP in cells.1
DP=diphosphate; PBMC=peripheral blood mononuclear cell; TAF=tenofovir alafenamide; TDF=tenofovir disoproxil fumarate.