DESCOVY® contains TAF, which more efficiently delivers tenofovir DP into PBMCs (including lymphocytes like CD4+ T cells) and macrophages vs TDF1-6
TAF delivers more active drug to lymphocytes vs TDF, resulting in less off-target drug exposure.
There’s no generic version of DESCOVY
FOR PrEP®.7
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*Plasma half-life: TAF=30 minutes; TDF=0.41 minutes.4
†Tenofovir is converted into tenofovir DP in cells.1
DP=diphosphate; PBMCs=peripheral blood mononuclear cells; PrEP=pre-exposure prophylaxis; TAF=tenofovir alafenamide; TDF=tenofovir disoproxil fumarate.