Not all HIV PrEP medication components are the same

DESCOVY® contains TAF, which more efficiently delivers tenofovir DP into PBMCs (including lymphocytes like CD4+ T cells) and macrophages vs TDF1-6

Graphic showing plasma half-life of tenofovir from TAF (tenofovir alafenamide) and TDF (tenofovir disoproxil fumarate) and levels in lymphocytes.

TAF delivers more active drug to lymphocytes vs TDF, resulting in less off-target drug exposure.

There’s no generic version of DESCOVY
FOR PrEP®
.7

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*Plasma half-life: TAF=30 minutes; TDF=0.41 minutes.4

†Tenofovir is converted into tenofovir DP in cells.1

DP=diphosphate; PBMCs=peripheral blood mononuclear cells; PrEP=pre-exposure prophylaxis; TAF=tenofovir alafenamide; TDF=tenofovir disoproxil fumarate.