TAF Pharmacology

PrEP drug molecules are different1-6

DESCOVY® contains TAF, which more efficiently delivers tenofovir DP into PBMCs (including lymphocytes like CD4+ T cells) and macrophages vs TDF1-4

Get the details on the only TAF-based PrEP medication.1

Graphic showing plasma half-life of tenofovir from TAF vs TDF and levels in lymphocytes.
  • TAF delivers more active drug to lymphocytes vs TDF, resulting in less off-target drug exposure
There’s no generic version of DESCOVY FOR PrEP®.
SEE EFFICACY DATA IN THE DISCOVER TRIAL

a Plasma half-life: TAF=30 minutes; TDF=0.41 minutes.4,6
b Tenofovir is converted into tenofovir DP in cells.1
DP=diphosphate; PBMC=peripheral blood mononuclear cell; TAF=tenofovir alafenamide; TDF=tenofovir disoproxil fumarate.